NCT05915260

CMR in T2DM: The NSR Cohort

Cardiac Magnetic Resonance Imaging in Type 2 Diabetes Mellitus: The Næstved/Slagelse/Ringsted Cohort

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 700 (estimated)
• Sponsor: Slagelse Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This study aims to investigate the myocardial phenotype of patients with type 2 diabetes. From 2016-2019 the investigators recruited a cohort of 296 subjects with type 2 diabetes. All subjects underwent clinical examinations including a gadolinium contrast cardiac MRI. The current study is a clinical follow-up study of the subjects, thus, the investigators will invite all participants to a reevaluation with cardiac MRI. Additionally, the investigators will aim at recruiting additionally 400 patients with type 2 diabetes. The aim it to characterize the phenotype of diabetic cardiomyopathy. Uniquely using cardiac MRI we can measure myocardial microvascular function, myocardial localised and diffuse fibrosis in addition to the quantification of myocardial structure and systolic and diastolic function.

Conditions

• Diabetes Mellitus, Type 2
• Diabetic Cardiomyopathies
• Cardiovascular Magnetic Resonance Imaging
• Coronary Microvascular Dysfunction
• Myocardium; Fibrosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	All subjects will undergo cardiac magnetic resonance imaging with gadolinium contrast and with adenosine myocardial perfusion	This is a observational follow up study accordingly all subjects will undergo the same examinations

Timeline

• Start date: 2023-04-01
• Primary completion: 2026-12-31
• Completion: 2030-01-31
• First posted: 2023-06-22
• Last updated: 2023-06-22

Locations

1 site across 1 country: Denmark