NCT05914896

Hyperosmolality and Acute Kidney Injury After Cardiac Surgery

Hyperosmolar Priming Solution for Cardiopulmonary Bypass May Increase the Risk for Postoperative Acute Kidney Injury: Results From Double-blinded Randomised Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Umeå University · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

The goal of this randomized controlled trial is to test if a hyperosmolar prime solution used for cardiopulmonary bypass increases the risk for acute postoperative kidney injury.

Detailed description

Two-hundred cardiac surgical patients were randomised into two groups based on the osmolality level of the prime solution used for cardiopulmonary bypass. The high osmolality group (966 mOsm) received a prime solution containing Ringer-Acetate 1000 ml + Mannitol 400 ml (60 g) + Sodium-Chloride 40 ml (160 mmol) and Heparin 2 ml (10 000 IU), while the reference group with normal osmolality (388 mOsm) received a prime solution containing Ringer-Acetate 1400 ml and Heparin 2 ml (10 000 IU).

Conditions

• Acute Kidney Injury
• Osmolality Disturbance
• Cardiopulmonary Bypass

Interventions

Type	Name	Description
DRUG	HighOsmo	This group received a priming solution with high osmolality

Timeline

• Start date: 2019-04-24
• Primary completion: 2020-06-24
• Completion: 2020-06-24
• First posted: 2023-06-22
• Last updated: 2023-06-22

Locations

1 site across 1 country: Sweden