Trials / Completed
CompletedNCT05889455
Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab
Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab: A Randomized Double-Blind Placebo-Controlled Two-Way Crossover Trial
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 16 (actual)
- Sponsor
- Danish Headache Center · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
An outstanding scientific question, that merits further investigation, is whether dilation of intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine. Here, we hypothesize that experimentally-induced dilation of intracranial arteries using intake of sildenafil (a potent vasodilator) can induce cephalic pain with migraine-like features in people with migraine, who prior to the infusion are administered erenumab (anti-calcitonin gene-related peptide (CGRP) receptor monoclonal antibody.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Sildenafil | Oral administration of 100mg |
| OTHER | Placebo | Placebo |
Timeline
- Start date
- 2023-04-20
- Primary completion
- 2023-10-12
- Completion
- 2023-10-12
- First posted
- 2023-06-05
- Last updated
- 2023-10-24
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT05889455. Inclusion in this directory is not an endorsement.