NCT05889312

Assessing Cancer Treatment Response to Therapy Using 18F-FSPG PET

Improving Response Assessment in Cancer by Measurement of Cellular Redox Status Using 18F-FSPG Positron Emission Tomography

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 32 (estimated)
• Sponsor: Guy's and St Thomas' NHS Foundation Trust · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

Prospective single centre non-randomised exploratory observational study to measure changes in tumour cellular redox status with 18F-FSPG PET in stage 3 non-small cell lung cancer (NSCLC) and stage 3 and 4 head and neck squamous cell cancer (HNSCC) at baseline and during standard of care treatment, and to compare this with 18F-FDG PET/CT and RECIST 1.1 response at 12 weeks.

Detailed description

Study design: Prospective single centre non-randomised exploratory observational study. Number of patients: 32 (16 head and neck cancer, 16 lung cancer). Primary hypothesis: Changes in 18F-FSPG uptake predict treatment efficacy. Primary objectives: To measure changes in tumour cellular redox status with 18F-FSPG PET in stage 3 non-small cell lung cancer (NSCLC) and stage 3 and 4 head and neck squamous cell cancer (HNSCC) at baseline and during standard of care treatment, and to compare this with 18F-FDG PET/CT and RECIST 1.1 response at 12 weeks. Secondary objectives: Characterise the uptake and pharmacokinetics of 18F-FSPG in NSCLC and HNSCC patients. Determine the baseline level and variability of 18F-FSPG uptake within and between patients with NSCLC and HNSCC pre and post treatment. Compare 18F-FSPG PET/CT imaging with standard measures of response (RECIST/PERCIST) and other clinical biomarkers (IHC and blood glutamate) at baseline and during cancer treatment. Primary outcomes: Report and compare % change in 18F-FSPG uptake in NSCLC and HNSCC patients on standard of care treatment with standard measures of response (RECIST/PERCIST) Secondary outcomes: Report variation in 18F-FSPG uptake in NSCLC and HNSCC. Report kinetic data in 18F-FSPG uptake in NSCLC and HNSCC. Report correlation of 18F-FSPG uptake in NSCLC and HNSCC with available histology and blood markers. Inclusion criteria: 1. Written informed consent 2. Aged 16 or above (as per NCRI) 3. Histologically confirmed NSCLC and HNSCC, who are treatment naïve and scheduled to commence standard of care treatment ((chemo)radiotherapy) 4. Willingness and ability to comply with scheduled study visits and tests 5. Confirmation of adequate function of all major organs and systems Exclusion criteria : 1. Pregnant or lactating women 2. Concomitant uncontrolled medical conditions 3. Participants likely to require palliative radiotherapy within the first 12 weeks of treatment 4. Prognosis less than 3 months 5. Previous anti-cancer treatment (only treatment naïve patients eligible for inclusion)

Conditions

• Cancer
• Diagnosis
• Resistant Cancer
• Response, Acute Phase

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	18F-FSPG PET/CT in NSCLC	Stage 3 NSCLC with radical curative intent at baseline (pre-treatment) and at 4-8 weeks into treatment.
DIAGNOSTIC_TEST	18F-FSPG PET/CT in HNSCC	Stage 3 and 4 HNSCC with radical curative intent at baseline and at 2-4 weeks into treatment.

Timeline

• Start date: 2025-02-19
• Primary completion: 2026-09-01
• Completion: 2027-09-01
• First posted: 2023-06-05
• Last updated: 2025-04-04

Locations

1 site across 1 country: United Kingdom