NCT05875883

Phrenic Identification in the ICU

Anatomical Landmarks for Identifying the Phrenic Nerve With Ultrasound in Intensive Care Unit

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 63 (estimated)
• Sponsor: Unity Health Toronto · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This will be a prospective observational study where the investigator will scan patients' necks with an ultrasound and look for anatomical landmarks that may help identify the phrenic nerve.

Detailed description

Patients under protective mechanical ventilation, an intervention that saves lives, may need sedation and paralyzing agents. However, sedation and paralyzing agents are associated with multiple complications, including diaphragm dysfunction. Several strategies have been proposed to reduce diaphram dysfunction. A novel approach is to stimulate the phrenic nerve, either transvenously or transcutaneously. Transvenous stimulation requires a catheter, which eventually is associated with increased risk of infection and thrombosis. In this scenario, transcutaneous phrenic nerve pacing is attractive but may be more susceptible to patients' anthropometric measures. The correlation between patients' anthropometric measures and the location of the phrenic has been poorly studied.

Conditions

• Ventilator Lung
• Ventilator-Induced Lung Injury
• Diaphragm Disease
• Phrenic Nerve
• Phrenic Nerve Stimulation
• Neck Anatomy
• Ultrasound

Interventions

Type	Name	Description
PROCEDURE	Neck ultrasound	The investigators will scan patients' necks with an ultrasound and look for anatomical landmarks to identify the phrenic nerve

Timeline

• Start date: 2024-04-21
• Primary completion: 2026-12-04
• Completion: 2026-12-04
• First posted: 2023-05-25
• Last updated: 2025-05-20

Locations

1 site across 1 country: Canada