NCT05848310

Preoperative Serum FGF19 in the Prognosis of Biliary Atresia

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Children's Hospital of Fudan University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

To investigate the role of preoperative serum FGF19 level in the prognosis of biliary atresia.

Detailed description

Kasai portoenterostomy is currently one of the main treatment methods for biliary atresia, but about 30% of children still require liver transplantation even after receiving the surgery. Accurate prognosis will help select the most suitable treatment method for children, but there is currently a lack of effective preoperative predictive indicators. Serum FGF19 has recently been considered a possible preoperative predictive indicator for biliary atresia, but its predictive value has not been confirmed in a large sample and in Asian population, thus the investigators try to further explore the prognostic value of serum FGF19 in children with biliary atresia based on a large sample.

Conditions

• Biliary Atresia
• Prognosis

Timeline

• Start date: 2023-10-15
• Primary completion: 2026-06-01
• Completion: 2027-08-01
• First posted: 2023-05-08
• Last updated: 2026-03-27

Locations

1 site across 1 country: China