NCT05843123

Comparison of Gas Exchange Between Two Invasive Mechanical Ventilation Modes in Children

Comparison of Carbon Dioxide Control During Pressure Controlled (PC) Versus Pressure Regulated Volume Control (PRVC) Ventilation in Children (CoCO2): a Digital, Randomized Controlled Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 59 (actual)
• Sponsor: University Children's Hospital, Zurich · Academic / Other
• Sex: All
• Age: 0 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

This study assesses the feasibility of digital data collection for a randomized controlled trial in a quaternary pediatric intensive care unit and the effect of two commonly used mechanical ventilation modes on gas exchange (CO2) in children over 2 days after randomization. This is a single-center, open-labelled, randomized controlled trial with two parallel 1:1 treatment arms: pressure controlled (PC) vs pressure-regulated volume controlled (PRVC) mechanical ventilation modes. Use to routine digital data is essential to enable health learning systems and to provide rapid clinical trials readiness, as the pandemic has demonstrated. Despite availability of data to perform digital trials in PICU settings, these are yet scarcely done.

Conditions

• Respiratory Failure

Interventions

Type	Name	Description
OTHER	Respiratory support a	Invasive mechanical ventilation mode
OTHER	Respiratory support b	Invasive mechanical ventilation mode

Timeline

• Start date: 2024-01-15
• Primary completion: 2024-09-20
• Completion: 2024-09-20
• First posted: 2023-05-06
• Last updated: 2024-12-13

Locations

1 site across 1 country: Switzerland