NCT05842616

Cerebral Pulsatility Index Compared To Mean Arterial Blood Pressure Guided Protocol In Sepsis Induced Encephalopathy:

Norepinephrine Titration In Patients With Sepsis Induced Encephalopathy: Cerebral Pulsatility Index Compared To Mean Arterial Blood Pressure Guided Protocol

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 112 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of our study is to compare between transcranial doppler pulsatility index and mean arterial blood pressure in guiding management of sepsis induced encephalopathy.

Detailed description

Sepsis induced encephalopathy is the most frequent sepsis related organ dysfunction. It appears early during the course of infection, often before any other organ involvement in up to 70% of hospitalized septic patients and is associated with significant change of cerebral circulation caused by redistribution of blood flow during sepsis that accompanies the abnormal inflammatory response during an infection, in absence of direct central nervous system involvement.

Conditions

• Sepsis
• Norepinephrine
• Encephalopathy

Interventions

Type	Name	Description
OTHER	Transcranial doppler pulsatility index guided protocol	Norepinephrine titration that will be guided by Transcranial doppler pulsatility index.
OTHER	Mean arterial blood pressure guided protocol	Norepinephrine titration that will be guided by Mean arterial blood pressure (MAP).

Timeline

• Start date: 2023-05-01
• Primary completion: 2024-06-30
• Completion: 2024-06-30
• First posted: 2023-05-06
• Last updated: 2024-08-06

Locations

1 site across 1 country: Egypt