NCT05836051

Testing the Effect of ENDS Flavors on Neurotransmission

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Milton S. Hershey Medical Center · Academic / Other
• Sex: All
• Age: 21 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The overarching goal of this translational proposal is to determine if neuroactive flavor chemicals can enhance the addiction potential of electronic nicotine delivery systems (ENDS) by altering brain function and behavior.

Detailed description

For this randomized double-blind controlled trial, tobacco users will be randomized to use ENDS with an e-liquid containing a neuroactive flavor (hexyl acetate) vs. an inactive flavor (ethyl acetate) for ten days as a supplement to their typical tobacco use. Laboratory measures of ENDS reinforcement, subjective ENDS ratings, and brain reactivity to the flavor using functional magnetic resonance imaging (fMRI) will be collected at baseline and after ten days of ENDS use.

Conditions

• Tobacco Dependence

Interventions

Type	Name	Description
OTHER	Flavor	E-liquid flavor chemicals

Timeline

• Start date: 2023-06-01
• Primary completion: 2025-05-30
• Completion: 2025-07-31
• First posted: 2023-05-01
• Last updated: 2025-09-25

Locations

1 site across 1 country: United States