NCT05834569

Impact of Maxigesic on Delirium After Minimally Invasive Lung Surgery in Elderly Patients

The Impact of Intravenous Administration of Perioperative Acetaminophen and Ibuprofen Combination (Maxigesic®) on Postoperative Delirium in Elderly Patients Undergoing Minimally Invasive Lung Segmentectomy or Lobectomy

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Korea University Guro Hospital · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

The primary aim of this interventional study is to investigate the impact of perioperative administration of Maxigesic (combination of acetaminophen and ibuprofen) on delirium after minimally invasive lung surgery in elderly patients. The Maxigesic group receives a total of 5 doses of Maxigesic (20mg/kg, maximum dose per serving: 1g) every 6 h from immediately after anesthesia induction. The control group receives the same volume of normal saline. Researchers compare the incidence and severity of postoperative delirium for 5 days after surgery.

Conditions

• Delirium
• Aged
• Lung Neoplasms
• Robotic Surgical Procedures
• Thoracic Surgery, Video-Assisted

Interventions

Type	Name	Description
DRUG	Acetaminophen and Ibuprofen	Patients in the Maxigesic group will be administered a total of 5 doses of the drug (20mg/kg, maximum dose per serving: 1g) every 6 h from immediately after anesthetic induction.
DRUG	Normal saline	Patients in the control group will be administered equal amounts of normal saline at the same time points.

Timeline

• Start date: 2023-06-15
• Primary completion: 2025-01-23
• Completion: 2025-01-23
• First posted: 2023-04-28
• Last updated: 2025-09-05

Locations

1 site across 1 country: South Korea