NCT05829694

Health Outcomes of Parents With Cystic Fibrosis

Health Outcomes of Parents With Cystic Fibrosis (HOPeCF): A Retrospective Analysis of Impact of Parenthood on Lung Function

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 956 (actual)
• Sponsor: University of Pittsburgh · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This project will determine the health impact of parenthood on people with cystic fibrosis (CF). The study team will use retrospective data to provide relatively immediate evidence on parenthood's effect on pulmonary health.

Detailed description

This co-funded study sponsored by the National Institutes of Health and the CF Foundation (CFF) will seek to determine the health impact of parenthood on people with CF in the era of CF transmembrane conductance regulator (CFTR) modulators. To provide relatively immediate evidence on parenthood's effect on pulmonary health and the influence of the introduction and use of all available CFTR modulators, in Aim 1 the study team will assess changes in pre- vs. intra-parenthood percent predicted forced expiratory volume in 1 second (ppFEV1) in a retrospective longitudinal cohort study linking CFF patient registry (CFFPR) data with cross-sectional surveys collected from 249 new parents attending participating United States CF centers between 2012-2022. The study team will identify predictors and timing of lung function loss using 747 non-parents from participating centers as a comparison group and examine the impact of CFTR modulators on parental health.

Conditions

• Cystic Fibrosis
• Parenthood Status

Interventions

Type	Name	Description
OTHER	Parental Status	The aim of the study is to assess the impact parenthood has on health outcomes.

Timeline

• Start date: 2023-07-12
• Primary completion: 2024-08-12
• Completion: 2024-08-12
• First posted: 2023-04-26
• Last updated: 2024-09-19

Locations

8 sites across 1 country: United States