Trials / Completed
CompletedNCT05816551
Aging and Gastrointestinal Barrier Function
Impact of Aging on Gastrointestinal Barrier Function During Hyperthermia
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 22 (actual)
- Sponsor
- University of Texas Southwestern Medical Center · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to assess the gastrointestinal responses of the elderly and younger populations during hyperthermia.
Detailed description
Heat waves are lethal and cause a disproportionate number of deaths in the elderly relative to any other age group. Although gastrointestinal barrier dysfunction is a primary cause of heat related illness, little is known about the effects of aging on gastrointestinal barrier function during hyperthermia. The central hypothesis of this work is that the elderly exhibit greater gastrointestinal barrier dysfunction during hyperthermia. Participants will complete a control trial where gastrointestinal permeability (without heating) will be assessed in young and older adults. In the experimental trial, controlled hyperthermia will be achieved using a water perfused, tube lined suit. Core body temperature will be raised to a maximum of 2 degrees Celsius above the baseline value, or an absolute temperature of 39.5 degrees Celsius. Core temperature will not be collected during the control trial. Comprehensive assessments of gastrointestinal barrier function and systemic inflammation will be assessed in young and older adults. The expected outcome of this work will re-shape our understanding of the consequences of aging on gastrointestinal barrier function during heat waves.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Hyperthermia Trial | Individuals will be exposed to a controlled hyperthermia trial during "Visit 2" of the protocol. |
| OTHER | Control Trial | Individuals will be exposed to a control trial (no hyperthermia) during "Visit 1" of the protocol. |
Timeline
- Start date
- 2023-07-01
- Primary completion
- 2024-09-30
- Completion
- 2024-09-30
- First posted
- 2023-04-18
- Last updated
- 2025-01-22
- Results posted
- 2025-01-22
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT05816551. Inclusion in this directory is not an endorsement.