NCT05810545

Drinking Water PFAS, Pregnancy Outcome and Maternal Morbidity

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 256,659 (actual)
• Sponsor: Karolinska Institutet · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The aim of the project is to assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e. growth retardation, premature birth, and congenital developmental defects) and maternal morbidity (gestational hypertension, diabetes and preeclampsia) in a prospective population-wide register study.

Conditions

• Birth Weight
• Small for Gestational Age at Delivery
• Large for Gestational Age at Delivery (Macrosomia)
• Diabetes, Gestational
• Hypertension in Pregnancy
• Preeclampsia
• Congenital Malformation

Interventions

Type	Name	Description
OTHER	Per- and polyfluoroalkyl substances (PFAS)	Assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e. growth retardation, premature birth, and congenital developmental defects) and maternal morbidity (gestational hypertension, diabetes and preeclampsia) in a prospective population-wide register based cohort.

Timeline

• Start date: 2012-01-01
• Primary completion: 2018-12-31
• Completion: 2018-12-31
• First posted: 2023-04-12
• Last updated: 2023-04-18