NCT05781672

Prediction of Delayed Toxic Cardiomyopathy in Children

Longitudinal Analysis of Myocardial Function by Speckle Tracking Echocardiography and Prediction of Delayed Toxic Cardiomyopathy Associated With Anthracycline Therapy in Children

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 134 (actual)
• Sponsor: University Hospital, Montpellier · Academic / Other
• Sex: All
• Age: 11 Years – 27 Years
• Healthy volunteers: Accepted

Summary

Longitudinal analysis of myocardial function using "Speckle Tracking Echocardiography" STE analysis and prediction of delayed toxic induced cardiomyopathy in young patients who received anthracycline therapy in childhood.

Detailed description

Anthracycline therapy may have short-, medium- or long-term cardiac toxicity that impacts patient's life. The main recognized risk factors for delayed cardiotoxicity are cumulative anthracycline dose, female gender, association with mediastinal radiotherapy and young age at administration. Prediction of delayed cardiotoxicity in children population is still challenging. The "Speckle Tracking Echocardiography" (STE) method, an innovative echocardiographic technique, analyses the myocardial displacement of natural acoustic markers via a software. The objective of the study is to analyze, in young patients who received anthracycline therapy in childhood, 5-years after their inclusion in the "Speckle Anthra" study and first STE results, the evolution of myocardial function using STE method.

Conditions

• Cardiotoxicity
• Childhood Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	cardiac ultrasound with speckle tracking analysis	Experimental group: cardiac ultrasound with speckle tracking analysis done during a regular cardiac visit planned after receiving cardiotoxic chemotherapy in childhood. Control group: cardiac ultrasound with speckle tracking analysis done during a cardiac visit for minor symptoms (murmur, physical aptitude). Advocated Tomtec software will be used to make post-processing speckle tracking analysis based on 2D ultrasound cineloop acquired during a standard echocardiography.

Timeline

• Start date: 2023-03-16
• Primary completion: 2025-01-07
• Completion: 2025-01-07
• First posted: 2023-03-23
• Last updated: 2025-02-19

Locations

1 site across 1 country: France