Trials / Unknown
UnknownNCT05779059
Prasugrel Or Ticagrelor De-escalation in NSTE-ACS
Prasugrel Or Ticagrelor De-escalation in Non-ST-elevation Acute Coronary Syndrome
- Status
- Unknown
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- Sponsor
- Collegium Medicum w Bydgoszczy · Academic / Other
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
The PROTEUS study is a randomized, cross-over, open-label, pharmacodynamic trial designed to compare the antiplatelet effect of reduced maintenance doses of prasugrel and ticagrelor in stable patients who recently had non-ST-elevation acute coronary syndrome (non-ST-elevation myocardial infarction or unstable angina).
Conditions
- Non ST Segment Elevation Acute Coronary Syndrome
- Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
- Unstable Angina
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | De-escalation to ticagrelor 60 mg at day 30 | Change of P2Y12 receptor antagonist regimen to ticagrelor 60 mg bid at day 30. |
| DRUG | De-escalation to prasugrel 5 mg at day 30 | Change of P2Y12 receptor antagonist regimen to prasugrel 5 mg qd at day 30. |
| DRUG | Switch to ticagrelor 60 mg at day 45 | Switch to ticagrelor 60 mg bid at day 45. |
| DRUG | Switch to prasugrel 5 mg at day 45 | Switch to prasugrel 5 mg qd at day 45. |
Timeline
- Start date
- 2023-04-01
- Primary completion
- 2024-12-31
- Completion
- 2024-12-31
- First posted
- 2023-03-22
- Last updated
- 2023-03-22
Locations
1 site across 1 country: Poland
Source: ClinicalTrials.gov record NCT05779059. Inclusion in this directory is not an endorsement.