NCT05770297

Effect of Propolis Administration for Dysmenorrhea in Endometriosis Patient With Levonorgestrel Implant Therapy

Effect of Propolis Administration as Levonorgestrel (LNG) Implant Adjuvant for Dysmenorrhea in Endometriosis: Focus on Clinical Improvement, Oxidative Stress Biomarkers and Inflammation

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Indonesia University · Academic / Other
• Sex: Female
• Age: 20 Years – 49 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to investigate the effect of propolis administration on dysmenorrhea in endometriosis patient. the main questions it aims to answer are: * Does the propolis administration reduce symptoms of dysmenorrhea in endometriosis? * Does the propolis administration reduce the amount of oxidative stress biomarkers in endometriosis? * Does the propolis administration reduce the amount of Inflammatory biomarkers in endometriosis? Participants will be given an intervention in the form of propolis at a dose of 1 drop per 10 kilogram of body weight per administration, twice a day. there will be a control group that will be given an intervention in the form of a placebo containing 70% caramel alcohol dye solution.

Conditions

• Endometriosis
• Dysmenorrhea

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Propolis	intervention will use propolis extract (liquid-based) with 1 drop/10kgBW/times, 2 times in a day for 12 weeks. propolis will be given to intervention group
OTHER	placebo	intervention will use placebo with 1 drop/10kgBW/times, 2 times in a day for 12 weeks. propolis will be given control group

Timeline

• Start date: 2022-07-12
• Primary completion: 2023-06-22
• Completion: 2023-07-11
• First posted: 2023-03-15
• Last updated: 2023-06-06

Locations

1 site across 1 country: Indonesia