NCT05765682

Mepivacaine Vs. Bupivacaine Spinal for TKA

Mepivacaine Vs. Bupivacaine Spinal: Effect on Return of Motor Function, Time to Ambulation, and Length of Stay in Total Knee Arthroplasty

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 160 (actual)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study will enroll patients 18-75 years of age who are undergoing elective primary total knee replacement. The patients will be randomized to receive one of two spinal blocks: 1) mepivacaine or 2) bupivacaine. The primary goal is to determine which group arrives at recovery of motor function first. Ultimately, this study will explore if mepivacaine leads to earlier return of motor function and ultimately earlier movement and discharge times following total knee replacement.

Conditions

• Total Knee Replacement

Interventions

Type	Name	Description
OTHER	Mepivacaine Spinal	spinal block using 60mg of mepivacaine
OTHER	Bupivacaine Spinal	spinal block using 10mg of bupivacaine

Timeline

• Start date: 2023-03-13
• Primary completion: 2024-08-23
• Completion: 2024-08-25
• First posted: 2023-03-13
• Last updated: 2024-09-19

Locations

1 site across 1 country: United States