Trials / Recruiting
RecruitingNCT05760339
Intermittent Fasting Versus Carbohydrate Drinks Before Surgery
Preoperative Intermittent Fasting Versus Carbohydrate Loading to Reduce Insulin Resistance: a Randomised Controlled Trial
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 75 (estimated)
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to investigate whether time-restricted feeding, a form of intermittent fasting, before surgery improves insulin resistance around the time of surgery, compared to carbohydrate drinks and standard fasting before surgery.
Detailed description
Patients in the Time-Restricted Feeding (TRF) group will follow a daily TRF regimen consisting of an 8h ad libitum eating period and a 16h water fasting period during the last two weeks before surgery, followed by routine preoperative fasting before surgery. Patients in the CarboHydrate Loading (CHL) group will follow their usual diet in the pre-surgical weeks and will receive a maltodextrin beverage on the evening before surgery, as well as two hours before induction of anaesthesia.
Conditions
- Perioperative Care
- Intermittent Fasting
- Carbohydrate Loading
- Preoperative Fasting
- Orthopedic Surgery
- Insulin Resistance
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Time-restricted feeding | Subjects in the will be instructed to follow a TRF regimen consisting of a daily 8h ad libitum eating period and 16h water fasting period during the last 2 weeks before surgery. Participants will be encouraged to begin their eating period at 08:00h and end it at 16:00h, since the metabolic benefits of TRF appear to be considerably more pronounced when the eating period starts early in the day. |
| DIETARY_SUPPLEMENT | Carbohydrate loading | Subjects will continue their usual diet and will receive two quantities of a clear beverage containing 12.5 g/100 mL maltodextrin (50 kCal/100 mL, pH 5.0); 800 mL at 22.00h on the evening before surgery and 400 mL two hours before anaesthesia induction. |
Timeline
- Start date
- 2023-03-20
- Primary completion
- 2025-09-01
- Completion
- 2025-09-01
- First posted
- 2023-03-08
- Last updated
- 2024-10-22
Locations
1 site across 1 country: Netherlands
Source: ClinicalTrials.gov record NCT05760339. Inclusion in this directory is not an endorsement.