Trials / Recruiting
RecruitingNCT05746039
Feasibility of Semaglutide in Advanced Lung Disease
Feasibility of Semaglutide Therapy for Weight Loss in Advanced Lung Disease: A Pilot Study
- Status
- Recruiting
- Phase
- Phase 1 / Phase 2
- Study type
- Interventional
- Enrollment
- 8 (estimated)
- Sponsor
- University of Pennsylvania · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question\[s\] it aims to answer are: 1. Are patients with advanced lung disease able to tolerate semaglutide therapy? 2. Are we able to titrate semaglutide therapy to a target weight? Participants will be asked to perform pulmonary function, physical function and body composition testing, as well as a blood draw before and after 12-weeks of semaglutide therapy. While on therapy, subjects will be surveyed regarding any adverse events or side effects.
Detailed description
This is a small open-label pilot clinical trial of semaglutide in adults (age 18 or older, n=8) with obesity (BMI≥30 kg/m2), and chronic advanced lung disease (interstitial lung disease, sarcoidosis, chronic obstructive pulmonary disease, or pulmonary hypertension requiring supplemental oxygen on exertion). This study will evaluate medication adherence and side effects to determine semaglutide tolerability. Markers of physical function and pulmonary function will be evaluated before therapy and after 12 weeks of therapy to determine the effect of semaglutide on function. Measures of fat and muscle, will be performed before therapy and after 12 weeks of therapy to evaluate how semaglutide alters body composition in this population. Study participants will be monitored for 12 weeks while receiving semaglutide therapy.
Conditions
- Obesity
- Interstitial Lung Disease
- Chronic Obstructive Pulmonary Disease
- Sarcoidosis, Pulmonary
- Pulmonary Hypertension
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Semaglutide Pen Injector | Once weekly subcutaneous injection |
Timeline
- Start date
- 2024-01-29
- Primary completion
- 2025-12-28
- Completion
- 2025-12-28
- First posted
- 2023-02-27
- Last updated
- 2025-03-17
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT05746039. Inclusion in this directory is not an endorsement.