NCT05739604

Serum Free Amino Acid Concentrations in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy (CRRT)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 26 (actual)
• Sponsor: Medical University of Gdansk · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Sepsis is a life-threatening condition associated with high morbidity and mortality. The breakdown of proteins mainly from skeletal muscles leads to the release of free amino acids (FAAs). The serum FAA pool has been repeatedly assessed and found to be significantly altered in patients with sepsis/septic shock. Sepsis is well known to be the most common factor contributing to the development of acute kidney injury in critically ill patients. The investigators want to establish the baseline profile of FAAs and their derivatives in patients with sepsis/septic shock undergoing continuous renal replacement therapy due to sepsis-associated acute kidney injury. Secondly, the investigators want to compare the FAA profiles of the survivors and nonsurvivors.

Conditions

• Sepsis
• Amino Acid Catabolism Disorder

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood sample analysis	The concentrations of AAs and related compounds were determined by liquid chromatography/mass spectrometry (LC/MS)

Timeline

• Start date: 2020-06-19
• Primary completion: 2022-09-10
• Completion: 2022-12-15
• First posted: 2023-02-22
• Last updated: 2023-02-22

Locations

1 site across 1 country: Poland