NCT05726500

Evaluation of Regional Ventilation Distribution in Patients Affected by Abdominal Sepsis After Emergent Laparotomy

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Università degli Studi di Ferrara · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to evaluate regional ventilation distribution in patients admitted to the intensive care unit after emergent laparotomy due to abdominal sepsis. The main question it aims to answer is: • evaluate if patients admitted after an open abdomen strategy have a different regional ventilation distribution compared to patients in which abdomen is closed at the end of the procedure Participants will undergo non-invasive monitoring (esophageal pressure and electrical impedance tomography) and an blood gas analysis samples. Researchers will compare open abdomen group and closed abdomen group to see if the ventilation distribution pattern is different.

Conditions

• Abdominal Sepsis
• Acute Respiratory Failure
• Ventilation Therapy; Complications
• Emergencies

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Arterial blood gas analysis	The researches will collect 2 ml of arterial blood using an arterial line already in place for clinical purposes to perform and arterial gas analysis.
DIAGNOSTIC_TEST	Venous blood gas analysis	The researches will collect 2 ml of arterial blood using a central venous line already in place for clinical purposes to perform a gas analysis.
DIAGNOSTIC_TEST	Esophageal pressure monitoring	The researchers will position an esophageal balloon to evaluate esophageal pressure
DIAGNOSTIC_TEST	Intrabdominal pressure	The researches will assess intrabdominal pressure using the urinary catheter system already in place for clinical purposes .
DIAGNOSTIC_TEST	Electrical impedance tomopgraphy	The researches will evaluate regional ventilation distribution using Electrical impedance tomography at different levels of positive end-expiratory pressure

Timeline

• Start date: 2023-02-15
• Primary completion: 2024-05-30
• Completion: 2024-12-31
• First posted: 2023-02-14
• Last updated: 2023-02-14

Locations

1 site across 1 country: Italy