NCT05725174

Volatile Non-Invasive Biomarkers of Epileptic Seizures

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 270 (estimated)
• Sponsor: University College London Hospitals · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Breath and sweat samples will be collected from people who have been admitted to hospital after a potential seizure and analysed by the team. The researchers then hope to identify a pattern of small molecules that can distinguish seizures from other events, and perhaps determine the severity of the seizure.

Detailed description

Determining whether someone has had an epileptic seizure, or another event, can be challenging and result in the wrong diagnosis. A 'seizure test' used after the event would therefore be very helpful. Researchers have used small molecules released from the body in breath and sweat to detect cancers and other diseases; this study will determine whether a similar method can be used to detect whether someone has had an epileptic seizure.

Conditions

• Epilepsy
• Non-Epileptic Seizure

Interventions

Type	Name	Description
OTHER	Sample Collection	Patients will have breath samples collected by blowing into a bag, and sweat samples collected by gauze. These samples will be collected at various timepoints whilst the patients are admitted on the ward.

Timeline

• Start date: 2023-01-30
• Primary completion: 2025-10-01
• Completion: 2026-11-01
• First posted: 2023-02-13
• Last updated: 2024-12-06

Locations

2 sites across 1 country: United Kingdom