NCT05724589

The Effectiveness of Epidermal Growth Factor Serum in Improve Facial Skin Hydration, Elasticity, Pigmentation, and Wrinkles.

The Effectiveness of Epidermal Growth Factor Serum for the Improvement of Facial Skin Hydration, Elasticity, Pigmentation, and Wrinkles at the Institute of Dermatology: a Single-centered Pilot Study With a One-group Before-and-after Design

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Institute of Dermatology, Thailand · Other Government
• Sex: All
• Age: 40 Years – 65 Years
• Healthy volunteers: Accepted

Summary

EGF is a polypeptide that promotes cell differentiation and collagen production while decreasing melanin production. This study is designed to study its effectiveness in improving the texture and appearance of facial skin after daily topical application. We hypothesized that EGF would improve facial skin hydration, elasticity, pigmentation, and wrinkles.

Detailed description

All patients gave written informed consent for epidermal growth factor serum application on the face. The pilot study enrolls thirty patients compared to pre and post-serum used to evaluate facial skin hydration, transepidermal water loss, elasticity, pigmentation, and wrinkles measured by corneometer, tewameter, cutometer, visioscan, and mexameter respectively on day 0, then 8, 12, and 16 weeks. The study evaluates subject satisfaction and side effects after serum application as secondary outcomes.

Conditions

• Aging

Interventions

Type	Name	Description
DRUG	Epidermal Growth Factor	Apply facial twice daily.

Timeline

• Start date: 2023-01-30
• Primary completion: 2024-06-05
• Completion: 2024-12-12
• First posted: 2023-02-13
• Last updated: 2025-07-31
• Results posted: 2025-07-31

Locations

1 site across 1 country: Thailand