Trials / Terminated
TerminatedNCT05723731
Effect of Transcutaneous Auricular Vagal Nerve Stimulation on Chronic Constipation
Effect of Transcutaneous Auricular Vagal Nerve Stimulation on Chronic Constipation: A Randomized Controlled Trial
- Status
- Terminated
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 106 (actual)
- Sponsor
- Air Force Military Medical University, China · Academic / Other
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
The worldwide prevalence of chronic constipation (CC) is 15%, and women are more likely to develop the disease than men. CC have a significant impact on quality of life and increase the burden of national health insurance. The conventional medication treatments are primarily symptom-specific and have limited efficacy. Previous small sample study had shown the therapeutic potential of transcutaneous auricular vagus nerve stimulation (taVNS) for irritable bowel syndrome with constipation (IBS-C). The aim of this study was to investigate whether taVNS could improve defecation condition and constipation symptoms in patients with CC.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | taVNS | Patients will receive taVNS (device produced by Xi'an Bashui Health Technology Co., Ltd) thirty minutes twice a day in the morning and the night for four weeks (duty circle: 30s "on" periods and 30s "off" periods; frequency: 25 Hz; amplitude of 0-2 mA at the maximum level that the patient could tolerate; pulse width: 0.5ms) |
| DRUG | Laxative Agent | Bisacodyl or glycerin enemas can be used in patients who do not have a bowel movement for more than 3 days. |
Timeline
- Start date
- 2023-01-03
- Primary completion
- 2023-07-31
- Completion
- 2023-09-28
- First posted
- 2023-02-13
- Last updated
- 2024-07-10
Locations
5 sites across 1 country: China
Source: ClinicalTrials.gov record NCT05723731. Inclusion in this directory is not an endorsement.