NCT05713097

TSI and Its Relationship With Graves' Disease Relapse

Thyroid-stimulating Immunoglobulins Level in Patients With Graves' Disease Undergoing Maintenance-dose of Antithyroid Drug and Its Relationship With Disease Relapse

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 352 (actual)
• Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to determine the role of TSI, as well as clinical signs and thyroid function tests in predicting Graves' disease (GD) relapse after withdrawing anti thyroid drug (ATD). The main questions it aims to answer are: 1. To investigate the serum TSI concentration in patients with GD undergoing maintenance-dose ATD. 2. To determine an optimal cut-off of TSI level for predicting GD relapse. 3. To determine the role of TSI in predicting Graves' disease relapse after withdrawing ATD.

Detailed description

Retrospective follow-up study of patients with hyperthyroidism due to Graves' disease, treated at the endocrine outpatient clinic of Medic Medical Center, Ho Chi Minh City from January 2000 to April 2021. TSI was measured several times during the course of treatment when planning to stop medication (at the discretion of the attending physician). ATD withdrawal would be planned when patients achieved euthyroid status clinically with normal FT4 tests for at least 3 months with minimal dose of ATD. The decision was also based on TSI concentration, goiter's characteristics and parenchymal vascularity on Doppler ultrasound.

Conditions

• Graves Disease
• Immunoglobulin
• Anti-Thyroid Antibodies Disorder

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	TSI	TSI was measured several times during the course of treatment when planning to stop medication (at the discretion of the attending physician).

Timeline

• Start date: 2022-01-02
• Primary completion: 2022-08-31
• Completion: 2022-08-31
• First posted: 2023-02-06
• Last updated: 2023-02-06

Locations

1 site across 1 country: Vietnam