NCT05703763

The Applanation Tonometry in GCA Pilot

The Applanation Tonometry in Giant Cell Arteritis Pilot

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 146 (estimated)
• Sponsor: Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal · Academic / Other
• Sex: All
• Age: 50 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

The Applanation Tonometry in Giant Cell Arteritis (ATOM-GCA) study will answer the following questions: 1. How does PWV, measured by applanation tonometry of temporal arteries, differ between patients with and without a final diagnosis of GCA (based on pre-defined criteria 6 months after inclusion)? 2. What is the diagnostic accuracy and positivity cutoff of the PWV, measured by applanation tonometry, in detecting: 1. A clinical diagnosis of GCA (based on pre-defined criteria 6 months after inclusion)? 2. Inflammation of temporal arteries on high-resolution ultrasound? 3. What is the acceptability and adherence of repeat applanation tonometry during the follow-up period in patients with GCA?

Detailed description

ATOM-GCA is a single-center, cross-sectional vanguard study.

Conditions

• Giant Cell Arteritis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Applanation tonometry	Applanation tonometry will be used to measure arterial stiffness in these segments, bilaterally: * Superficial temporal artery to frontal temporal artery * Common carotid artery to superficial temporal artery
DIAGNOSTIC_TEST	Standardized GCA assessment	Clinical assessment, blood test review, high-resolution temporal artery ultrasound using a 24mHz probe.
DIAGNOSTIC_TEST	Repeat applanation tonometry (optional)	Repeat index test at month 6 and at disease relapse.

Timeline

• Start date: 2025-07-30
• Primary completion: 2026-06-01
• Completion: 2027-07-01
• First posted: 2023-01-30
• Last updated: 2025-08-07

Locations

1 site across 1 country: Canada