NCT05694962

Low-Dose Radiation Therapy for Severe COVID-19 Pneumonia

Low-Dose Radiation Therapy for Severe COVID-19 Pneumonia: A Multicenter Phase II Prospective Randomized Controlled Study

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Jiangsu Cancer Institute & Hospital · Academic / Other
• Sex: All
• Age: 40 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This phase II trial studies low-dose radiation therapy as a treatment for patients with severe COVID-19 pneumonia to improve clinical status.

Detailed description

PRIMARY OBJECTIVE: I. To compare treatment of severe COVID-19 pneumonia between supportive care and standard of care drug therapies versus supportive care and standard of care drug therapies plus low-dose, whole-lung radiation therapy OUTLINE: Patients undergo 1.5Gy of single low-dose radiation therapy. After completion of study treatment, patients are followed up at days 1-7, and 14 after last dose of intervention.

Conditions

• COVID-19 Pneumonia

Interventions

Type	Name	Description
RADIATION	Low-Dose Radiation Therapy	1.5Gy single treatment of whole-lung radiation therapy

Timeline

• Start date: 2023-01-01
• Primary completion: 2024-12-01
• Completion: 2024-12-01
• First posted: 2023-01-23
• Last updated: 2023-01-25