NCT05674084

Vasopressor Support, Mean Arterial Pressure and Capillary Refill Time in Critically Ill Patients

Influence of Vasopressor Support and Mean Arterial Pressure on Capillary Refill Time Values in Critically Ill Patients: Prospective, Observational Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Medical University of Silesia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in crtically ill patients. The main questions it aims to answer are: * How do vasopressor drugs determine CRT value * How does mean arterial pressure (MAP) determine CRT value * How often CRT value is normal (\< 3 sec) despite hypotensive MAP (\<65 mmHg) Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value.

Detailed description

The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in critically ill patients. The main questions it aims to answer are: * How does norepinephrine dose influence CRT value * How does epinephrine dose influence CRT value * How does argipressin dose influence CRT value * How does dobutamine dose influence CRT value * How does mean arterial pressure (MAP) determine CRT value * How often CRT value is normal (\< 3 sec) despite hypotensive MAP (\<65 mmHg) Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value. CRT will be a dependent variable. Independent variables will be as follows: age, MAP, norepinephrine dose, epinephrine dose, argipressin dose, dobutamine dose. CRT measurements will be performed in a standarized rigor (light, chronometer, pressure and ambient temperature will be the same in all patients)

Conditions

• Critical Illness

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Capillary refill time	CRT will be measured by applying firm pressure to the ventral surface of the index finger distal phalanx with a glass microscope slide. The pressure will be increased until the skin is blank and then maintained for 10 seconds. The time for return of the normal skin color will be registered with a chronometer, and \> 3 seconds is defined as abnormal. Light and ambient temperature will be the same for all individuals.

Timeline

• Start date: 2022-12-03
• Primary completion: 2023-10-31
• Completion: 2023-12-31
• First posted: 2023-01-06
• Last updated: 2023-01-06

Locations

1 site across 1 country: Poland