NCT05670093

Neural Pressure Support, Synchrony and Respiratory Muscle Unloading

Neural Pressure Support, a Randomized Crossover Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (estimated)
• Sponsor: Karolinska Institutet · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In this study patients who are intubated and on ventilator for more than 24h will be ventilated at three different level of support in Pressure Support and Neural Pressure Support to study patient-ventilator synchrony and muscle unloading.

Detailed description

This study is an interventional randomized crossover study in intubated and mechanically ventilated patients for more than 24h. Eligible patients from whom informed consent is obtained and Pes and Edi catheter are successfully positioned are enrolled in the study. Patients will be ventilated in Pressure Support and Neural Pressure Support at three different level of assist (baseline, 50% and 150% of baseline respectively) in randomized order. Ventilator curves will be recorded and bloodgas obtained at the end of each study step, each lasting 20min.

Conditions

• Acute Respiratory Failure

Interventions

Type	Name	Description
DEVICE	Neural Pressure Support (mode of mechanical ventilation)	Nasogastric tube will be removed and replaced by a Esophageal catheter and Electrical Diaphragm activity catheter and mechanical ventilation in mode Neural Pressure Support

Timeline

• Start date: 2022-05-17
• Primary completion: 2025-12-31
• Completion: 2026-06-01
• First posted: 2023-01-04
• Last updated: 2024-09-19

Locations

1 site across 1 country: Sweden