NCT05668832

Bioavailability of Vitamin D Photoisomers From UVB-exposed Button Mushrooms

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (estimated)
• Sponsor: Martin-Luther-Universität Halle-Wittenberg · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The European Food Safety Authority has approved many applications for UVB light treated foods (e.g. UVB-exposed button mushrooms) in the last years. The UVB light treatment is used to increase the vitamin D content in foods and improve the vitamin D status of subjects. However, UVB irradiation is accompanied by the formation of vitamin D photoisomers such as lumisterol and tachysterol. The current study aims to investigated whether these vitamin D photoisomers can enter the circulation and are metabolised in humans that consume UVB-treated mushrooms.

Detailed description

according to protocol

Conditions

• Dietary Exposure
• Safety Issues

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	UVB-exposed button mushrooms	Healthy subjects will be randomized into two groups and received either UVB-exposed button mushrooms or non-UVB-exposed button mushrooms for 7 days. Blood samples from each subject will be taken at baseline (before the intake of the mushrooms, 3 h and 6 h thereafter, and at day 8. Three months later, another blood sample was taken.

Timeline

• Start date: 2023-01-09
• Primary completion: 2023-07-30
• Completion: 2024-07-30
• First posted: 2022-12-30
• Last updated: 2022-12-30