Trials / Unknown
UnknownNCT05668559
Transcranial Magnetic Stimulation and Perioperative Neurocognitive Disorders
The Effects of rTMS on Postoperative Cognitive Function in Patients After Cardiac Surgery
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 280 (estimated)
- Sponsor
- Anshi Wu · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
To investigate the impact of rTMS on the incidence of perioperative neurocognitive disorders in patients after after cardiac surgerysurgery. To explore the underlying mechanisms behind the efficacy.
Detailed description
There is a relatively high incidence of perioperative neurocognitive disorders（PND） after surgeries, and the incidence is even higher in the geriatric population undergoing cardiac surgery. Nevertheless, there remains no effective medication or intervention been approved in PND. It has been shown that brain stimulation can improve cognitive function in mild cognitively impaired patients. However, the effects on cognitive function in PND remain uninvestigated.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | repetitive transcranial magnetic stimulation | The rTMS mode consists of a cluster stimulus delivered every 0.2 seconds (5 Hz), with each cluster stimulus consisting of three burst stimuli with a 50 Hz body frequency. The duration of a single stimulus was approximately 40 seconds, for a total of 600 pulses. Stimulation takes place bilaterally in the dorsolateral prefrontal cortex (DLPFC). All enrolled patient in the rTMS group will receive 1 set simulation per day with an intersession interval (ISI) of over 30 minutes on postoperative day 1 to 5 after the surgery. |
| PROCEDURE | Sham Stimulation | Shaman stimulation uses the same protocol (600 pulses per session, 3 sessions per set, ISI≥30 min, 3 sets) with the coil set at 90 against the skull on postoperative day 1 to 5 after the surgery. |
Timeline
- Start date
- 2023-10-01
- Primary completion
- 2026-03-01
- Completion
- 2026-04-01
- First posted
- 2022-12-30
- Last updated
- 2023-09-05
Source: ClinicalTrials.gov record NCT05668559. Inclusion in this directory is not an endorsement.