NCT05646186

Personalized Dietary Intervention Based on Microbiome Analysis vs FODMAP Diet for Irritable Bowel Syndrome

Comparison of Personalized Diet Implementation Based on Microbiome Analysis and FODMAP Diet Efficacy in Irritable Bowel Syndrome

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Istanbul Medipol University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

irritable bowel syndrome (IBS) is a well-known risk factor for diseases of the anal region (hemorrhoids, anal fissures, etc.) and large intestine (colon cancer, diverticular disease). Untreatable IBS disease not only impairs the patient's quality of life but also reduces the success of surgical treatment in these diseases. Today, only one-third of IBS patients achieve successful results with the treatment methods and diets used routinely. Balancing the composition of the gut microbiota may yield satisfactory results in this patient group. With the results of our study, we aim to reveal the effect of microbiome analysis and personalized diet on symptoms and its place in treatment in patients with IBS disease. Patients applying to Gastroenterology outpatient clinics in respective centers due to IBS will be randomized into two groups. The patients in the control group will follow the FODMAP diet protocol for IBS; In the study group, a personalized diet will be applied according to the gut microbiota. No nutritional supplements will be used in either group. Changes in defecation habits and quality of life scale of both groups will be evaluated at the end of 6 weeks and the results will be compared.

Conditions

• Irritable Bowel Syndrome
• Irritable Bowel Syndrome With Diarrhea
• Irritable Bowel Syndrome With Constipation
• Irritable Bowel Syndrome Mixed

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Personalized dietary intervention based on microbiome analysis	Personalized dietary intervention based on individual microbiome analysis
DIETARY_SUPPLEMENT	Low-FODMAP diet	Low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols diet

Timeline

• Start date: 2022-10-01
• Primary completion: 2023-01-30
• Completion: 2023-12-31
• First posted: 2022-12-12
• Last updated: 2022-12-12

Locations

1 site across 1 country: Turkey (Türkiye)