NCT05643911

Effects of High-flow Oxygen Therapy and Non-invasive Ventilation on Lung Volumes and on Upper Airway

Effects of High-flow Oxygen Therapy and Non-invasive Ventilation on Lung Volumes and on Upper Airway in Hypoxemic Critical Care Patients: a Physiological Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 56 (estimated)
• Sponsor: University Hospital, Montpellier · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Respiratory failure is the most frequent organ failure and cause for admission in the Intensive Care Unit (ICU) . It is a severe complication with an ICU mortality ranged from 31% to 33%. Symptomatic treatment of hypoxemic respiratory failure is a controversial topic with different options: 1) standard oxygen therapy, 2) high flow nasal cannula oxygen therapy (HFNC) and 3) non-invasive ventilation (NIV). The aim of the study is to compare HFNC versus NIV ventilation using CT scan. The hypothesis of this study is that in hypoxemic critically ill patients, the increase of lung volumes with NIV would be significantly higher than the increase of lung volumes with HFNC.

Conditions

• Respiratory Failure

Interventions

Type	Name	Description
PROCEDURE	HFNC	In the HFNC group, patients will receive HFNC oxygen therapy for 20 minutes.
PROCEDURE	NIV	Patients will receive NIV for 20 minutes delivered with a naso-buccal or face mask according to the patient's tolerance.

Timeline

• Start date: 2023-01-27
• Primary completion: 2025-01-01
• Completion: 2025-01-01
• First posted: 2022-12-09
• Last updated: 2024-05-29

Locations

1 site across 1 country: France