NCT05642624

The PK/PD of Deoxycholic Acid Amphotericin B in Invasive Fungal Infection Patients With Sepsis/Septic Shock

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: Southeast University, China · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

To explore the PK/PD of deoxycholic amphotericin B in invasive fungal infection patients with sepsis/septic shock;To compare the PK/PD of deoxycholic amphotericin B in invasive fungal infection patients with sepsis and septic shock.

Detailed description

This was a single-center study.Patients who were diagnosed with in invasive fungal infection receieved deoxycholic acid amphotericin B during the study period.The information was recored including the general condition, infection index, PK/PD index and drug-related side effects.

Conditions

• Fungal Infection

Interventions

Type	Name	Description
DRUG	Deoxycholic acid amphotericin B	Starting with 1mg and increasing by 5-25mg daily until the maintenance dose is 50mg/d.

Timeline

• Start date: 2019-02-28
• Primary completion: 2022-06-28
• Completion: 2022-06-28
• First posted: 2022-12-08
• Last updated: 2022-12-08

Locations

2 sites across 1 country: China