NCT05634083

Does Indoxyl Sulfate Have a Role in Uremic Pruritus?

Does Indoxyl Sulfate Have a Role in Uremic Pruritus? A Laboratory and Interventional Study.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Benha University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

Itching is a widespread and disturbing complain from patients with chronic kidney disease (CKD); epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe itching. The pathogenesis of renal pruritus is multifactorial. Triggering factors may include uremia-related abnormalities, accumulation of uremic toxins, systemic inflammation and cutaneous xerosis. Indoxyl sulfate (IS) is a protein-bound uremic toxin resulting from the metabolism of dietary tryptophan accumulating in patients with end-stage renal disease.

Detailed description

Patients with end-stage renal disease undergoing hemodialysis complaining of itching not related to other cause than renal failure will take activated charcoal with foods and serum level of indoxyl sulphate will be studied

Conditions

• Pruritus

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Uremic pateints with itching	Activated charcoal

Timeline

• Start date: 2022-11-25
• Primary completion: 2022-12-31
• Completion: 2023-01-22
• First posted: 2022-12-01
• Last updated: 2023-02-08

Locations

2 sites across 1 country: Egypt