Trials / Completed
CompletedNCT05628805
Theta Burst Stimulation to Improve Inhibitory Motor Physiology in Tourette Syndrome
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 16 (actual)
- Sponsor
- Children's Hospital Medical Center, Cincinnati · Academic / Other
- Sex
- All
- Age
- 10 Years – 21 Years
- Healthy volunteers
- Not accepted
Summary
Decades of Tourette Syndrome (TS) neuroimaging research has revealed abnormal cortical and subcortical motor system network, hypothesized to result from maladaptive plasticity. Repetitive transcranial magnetic stimulation (\[r\]TMS) is a promising technology that utilizes the concept of neuroplasticity to modulate brain circuits. TMS modulation has the distinct advantage in terms of its non-invasive nature. Furthermore, unique stimulation paradigms such as intermittent theta-burst repetitive TMS (iTBS) allows for short stimulation time (\<3 min). Using a sham-controlled protocol, the investigators propose modulating pre-SMA output using iTBS, based on our prior data of abnormal pre-SMA-mediated motor system regulation. hypothesize pre-SMA modulation results in increased pre-SMA-mediated motor inhibition. Enhancing these inhibitory measures with pre-SMA-iTBS provides the basis for improving inhibitory function in TS patients, leading to our long-term goal of neuro-stimulation to achieve clinical tic reduction.
Conditions
- Tourette Syndrome
- Tourette Syndrome in Children
- Tourette Syndrome in Adolescence
- Tourette Syndrome, Modifier of
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | iTBS | intermittent theta burst stimulation with TMS |
Timeline
- Start date
- 2022-11-01
- Primary completion
- 2026-02-16
- Completion
- 2026-02-16
- First posted
- 2022-11-29
- Last updated
- 2026-03-18
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated device study
Source: ClinicalTrials.gov record NCT05628805. Inclusion in this directory is not an endorsement.