NCT05627817

Timing of Preload Responsiveness in Sepsis

Timing of Preload Responsiveness in Sepsis and Septic Shock

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Bicetre Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

During acute circulatory failure, volume expansion does not always lead to a significant increase in cardiac output (fluid responsiveness). After initial resuscitation by rapid fluid administration, cardiac preload is no longer extremely low and only half of the patients respond to further volume expansion with the expected increase in cardiac output (fluid unresponsiveness). However, the time delay or the volume of fluid needed to be administered from the state of fluid responsiveness to fluid unresponsiveness is still not determined. Objective To determine, in critically ill patients with acute circulatory failure, 1. : the time and/or the volume of fluid needed from the state of fluid responsiveness to fluid unresponsiveness during septic shock. 2. : determine the factors that influence this time and volume.

Conditions

• Septic Shock
• Fluid Responsiveness

Timeline

• Start date: 2019-02-20
• Primary completion: 2023-06-01
• Completion: 2023-12-01
• First posted: 2022-11-28
• Last updated: 2022-11-28

Locations

1 site across 1 country: France