NCT05599217

Association Between Dietary Factors and Chronic Subdural Hematoma (DISH)

Association Between Dietary Factors and Chronic Subdural Hematoma: a Multicenter Case-control Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 420 (estimated)
• Sponsor: Beijing Tiantan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

A prospective, multicenter, case control trial is designed to compare difference in dietary and nutritional factors in patients with and without chronic subdural hematoma.

Detailed description

Chronic subdural hematoma (CSDH) is one of the most common neurosurgical conditions, which is considered to be an inflammatory disease. Dietary factors can have an impact on the inflammatory mechanism in human body, which can increase a variety of inflammatory biomarkers in the blood. The risk of malnutrition in the elderly is generally high, and nutritional status can affect the risk of CSDH in the elderly. Little is known about the association of dietary factors with CSDH. The investigators speculate that dietary factors participate in and promote the occurrence and development of CSDH. This study will clarify whether there is a correlation between dietary factors and CSDH, which will reveal the pathogenesis and prevention of CSDH.

Conditions

• Chronic Subdural Hematoma

Interventions

Type	Name	Description
OTHER	Dietary and nutritional questionnaire	Nutrition assessment, nutrient intake, dietary inflammatory index, and frailty status will be examined using questionnaires.
OTHER	Neurological function, cognitive function, and life quality assessment	Neurological function, cognitive function, and life quality will be examined using Glasgow Coma Scale, Modified Rankin Scale, Markwalder Grade Scale, Mini-mental state examination, and EuroQol five dimensions questionnaire.
OTHER	Peripheral blood test	Collect peripheral blood samples from patients.
OTHER	Metabonomic test	Collect urine and stool samples from patients.
OTHER	Hematoma test	Collect hematoma fluid, dura mater, and hematoma outer membrane samples from patients.

Timeline

• Start date: 2023-03-13
• Primary completion: 2024-12-31
• Completion: 2025-03-31
• First posted: 2022-10-31
• Last updated: 2024-04-22

Locations

4 sites across 1 country: China