NCT05581745

A2 to O Lung Transplants

Blood Group A2 Donor to Blood Group O Recipient Lung Transplantation

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: University Health Network, Toronto · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Blood group A2 to blood group O kidney and liver transplants have been shown to be safe and successful, especially in recipients with low pre-operative anti-A antibody titers and with the use of peri-operative antibody-depleting therapies. Since blood group O lung transplant candidates tend to have longer wait times and a higher waitlist mortality compared to other blood groups, we propose to conduct a prospective study of lung transplantation from blood group A2 donors to eligible blood group O recipients in an effort to increase the available donor pool. The aim of this study is to determine both the feasibility and safety of this specific type of ABO-incompatible lung transplant, and the impact of this practice on reducing transplant wait times among blood group O lung transplant candidates. This would represent the first prospective study of ABO-incompatible lung transplants worldwide.

Conditions

• Lung Transplant
• ABO Incompatibility

Interventions

Type	Name	Description
PROCEDURE	Blood group A2 donor to blood group O recipient lung transplant surgery	Suitable blood group A2 donor lung transplant to a consented blood group O recipient who has acceptably low levels of anti-A antibody titres and a negative virtual cross-match at time of transplant

Timeline

• Start date: 2022-07-14
• Primary completion: 2026-12-31
• Completion: 2033-12-31
• First posted: 2022-10-14
• Last updated: 2025-02-06

Locations

1 site across 1 country: Canada