NCT05580198

Prognostic Markers of Post-Stroke Depression (PROMoSD)

Prognostic Markers of Post-Stroke Depression: A Single-center Prospective Observational Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 105 (estimated)
• Sponsor: Ruhr University of Bochum · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Single-center prospective observational study investigating the association of brainstem raphe hypoechogenicity detected by transcranial sonography and post-stroke depression three months after an acute ischemic stroke.

Detailed description

Post-stroke depression (PSD) is an important complication after a stroke. Despite significant limitations between studies of PSD risk factors, stroke severity or post-stroke disability, prior depressive episodes, and female sex are arguably the most well-known risk factors for developing PSD, although the predictive value of these factors is limited. A hypoechogenic brainstem raphe (BR) detected by transcranial sonography (TCS) is associated with depressive symptoms in distinct diseases but is also common with approximately 25% of the non-depressed population in Europe. The primary aim of this study is to investigate the association between BR hypoechogenicity and PSD occurrence in a prospective observational study design.

Conditions

• Acute Ischemic Stroke

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Transcranial sonography.	Transcranial sonography examination to determine the brainstem raphe echogenicity.

Timeline

• Start date: 2021-01-01
• Primary completion: 2022-11-01
• Completion: 2023-03-01
• First posted: 2022-10-14
• Last updated: 2022-10-17

Locations

1 site across 1 country: Germany