NCT05578183

Therapeutic Effect of Transcranial Magnetic Stimulation on Memory Impairment in Patients After Stroke

Therapeutic Efficacy and Mechanism of Personalized Theta Burst Stimulation on Working Memory Impairment in Patients After Stroke

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: China Rehabilitation Research Center · Other Government
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to test the therapeutic effect of theta burst stimulation (TBS), which is one of stimulus pattern of repetitive transcranial magnetic stimulation, in patients with post stroke cognition impairment (PSCI). The main questions it aims to answer are: 1. To explore the therapeutic effect of TBS to patients with PSCI. 2. To compare effect of TBS with different dose. 3. To explore the mechanism of TBS by functional magnetic resonance imaging (fMRI). Participants will be asked to do: 1. Treated with TBS and cognitive training for 3 weeks (15 days). 2. Assessed with several scales, including Mini-mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Loewenstein Occupational Therapy Cognitive Assessment (LOTCA), Wechsler Adult Intelligence Scale-revised in China (WAIS-RC), Wechsler Memory Scale (WMS) before and after treatment. 3. Perform the resting fMRI, electroencephalogram (EEG) and event related potential before and after treatment. Researchers will compare high-dose group, low-dose group and sham group to see if TBS play a role in PSCI and if the effect of high dose TBS was stronger than low dose.

Detailed description

the procedure of study 1. Patients were recruited and agreed with Informed Consent. 2. All patients were assessed with MMSE, MoCA, LOTCA, WAIS and WMS, meanwhile they conduct fMRI and EEG. Target of TBS set at dorsolateral prefrontal cortex (DLPFC). 3. TBS was performed for 15 days (5 days \* 3 weeks). 4. Within 3 days after TBS, all patients were assessed with MMSE, MoCA, LOTCA, WAIS and WMS, meanwhile they conduct fMRI and EEG. 5. Data acquisition and analysis.

Conditions

• Stroke
• Stroke Sequelae
• Cognitive Impairment

Interventions

Type	Name	Description
DEVICE	theta burst stimulation	expect for the TBS, all patients get cognitive training alike on a training system in medical center.
DEVICE	sham stimulation	expect for the TBS, all patients get cognitive training alike on a training system in medical center.

Timeline

• Start date: 2022-12-31
• Primary completion: 2023-12-31
• Completion: 2023-12-31
• First posted: 2022-10-13
• Last updated: 2022-12-08

Locations

1 site across 1 country: China