NCT05576428

Efficacy of N-Acetylcysteine in Improving/Normalizing ALT & AST in Patients of NAFLD

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Dow University of Health Sciences · Academic / Other
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Currently researches are focusing on the effect of antioxidants in the treatment of non-alcoholic fatty liver disease (NAFLD). Since N-acetyl cysteine (NAC) has been proven to have antioxidant and anti-inflammatory properties, therefore, we will conduct this study to determine the effect of NAC in patients of NAFLD with raised liver enzymes.

Detailed description

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing globally, and presents a challenge for the medical community since it has no FDA approved treatment. An important feature of non-alcoholic fatty liver disease (NAFLD) is hepatic steatosis leading to hepatic dysfunction . It has been reported that NAFLD patients with increased liver enzymes have a greater risk of developing complications like cirrhosis and end-stage liver disease. since N-acetyl cysteine (NAC) has been proven to have antioxidant and anti-inflammatory properties, therefore, we will conduct this study to determine the effect of NAC in patients of NAFLD with raised liver enzymes (ALT, AST). Patients presenting with ultrasound showing fatty liver with raised liver enzymes will be recruited. They will be randomized into two groups (group A and group B). The odd number patients will be allocated group A and even number patients will be allocated to group B. Group A: patients in this group will be advised to follow a diet plan \& daily 20 minutes brisk walking. Group B: Patients in this group will be given NAC 200mg BD along with diet plan \& exercise. This drug will be provided to the patients by the investigators free of cost. The liver function tests and side effects of NAC will be followed at 12 weeks .

Conditions

• NAFLD

Interventions

Type	Name	Description
BEHAVIORAL	Diet and exercise	diet and exercise in patients of NAFLD
DRUG	NAC with diet and exercise	NAC with diet and exercise in patients of NAFLD

Timeline

• Start date: 2022-11-01
• Primary completion: 2023-04-30
• Completion: 2023-05-15
• First posted: 2022-10-12
• Last updated: 2022-10-28