NCT05574140

BreathinG-induced Myocardial and Cerebral Perfusion in Anxiety Disorders

BreathinG-induced Myocardial and Cerebral Perfusion in Anxiety Disorders (B-GLAD)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 84 (estimated)
• Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This study aims to view variations in MRI measurements of the heart and the brain in people with anxiety versus healthy volunteers. The MRI measurements used will be Oxygenation-Sensitive Cardiac MRI (OS-CMR), a recent type of MRI which is safe, fast, and non-invasive.

Detailed description

The investigators will prospectively analyze OS-CMR data from patients with a generalized anxiety disorder from one site. The investigators will observe how an anxiety disorder affects the OS-CMR data. In a follow-up MRI scan, the investigators will look at the OS-CMR of a subgroup who have anxiety disorder and are also undertaking cognitive behavioural therapy to asses how and if this therapy affects the OS-CMR data.

Conditions

• Generalized Anxiety Disorder
• Oxygenation Sensitive CMR

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Cardiac MRI	The 4-minute breathing maneuver comprised of 2 minutes of normal breathing and 1-min hyperventilation (rate of 30 breaths per minute) followed by a maximal breath-hold. This technique is used in Oxygenation Sensitive CMR, a type of MRI, and will induce a vasoactive response visible in cardiac and cerebral MRI images

Timeline

• Start date: 2022-07-15
• Primary completion: 2025-03-15
• Completion: 2025-09-15
• First posted: 2022-10-10
• Last updated: 2024-10-24

Locations

1 site across 1 country: Canada