NCT05572320

Platelet Function and Neurological Events

Platelet Function and Neurological Events Following Carotid Thromboendarterectomy

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 386 (estimated)
• Sponsor: Scientific Institute San Raffaele · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Several studies have shown an association between platelet function and stroke in patients undergoing carotid thromboendarterectomy (TEA). The present study will assess the correlation between platelet function evaluated by the impedance aggregometry and neurological events in patients undergoing carotid TEA.

Detailed description

Carotid thrombendarterectomy (TEA) is effective in preventing strokes which are a major cause of mortality and morbidity. Nevertheless, almost 10% of patients undergoing TEA develop a transient and/or permanent neurological injury. There is a growing body of evidence that platelet function is associated with perioperative neurological events in this setting, although the vast majority of patients undergoing carotid TEA are already on antiplatelet agents. The aim of the present study will be to assess the correlation between the platelet function evaluated by the impedance aggregometry (Multiplate ® Analyzer, Roche, Basel, Switzerland) and neurological events in patients undergoing carotid TEA.

Conditions

• Stroke, Acute
• Carotid Artery Diseases

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Platelet Aggregometry Testing	1.6 ml of blood collected in hirudin-coated tubes before the surgery

Timeline

• Start date: 2022-10-10
• Primary completion: 2024-09-20
• Completion: 2025-09-20
• First posted: 2022-10-07
• Last updated: 2024-01-24

Locations

1 site across 1 country: Italy