NCT05571709

The Effect of Exercise on Myokine Production in Aging Persons

Does an Acute Exercise Bout Increases Soluble and Muscle Myokine Concentration in Healthy, Older Persons

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Hasselt University · Academic / Other
• Sex: All
• Age: 65 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The incidence of age-related diseases, such as cancer and cardiovascular diseases, rapidly rises. These days, age-related diseases cause the majority of all healthcare expenses. During ageing senescent cells secrete a range of harmful inflammatory signals, which leads to chronic inflammation (inflamm-aging) and accelerates aging throughout the rest of the body. Interestingly, people who regularly exercise show less signs of inflamm-aging compared to people with a sedentary lifestyle. Molecules secreted by skeletal muscles, called myokines, may play an important role. However, the underlying molecular mechanisms remain unknown. This pilot study aims to investigate if an acute bout of resistance training is an appropriate tool to induce an increase in the release of muscle derived myokines in aged persons.

Conditions

• Aging
• Exercise

Interventions

Type	Name	Description
OTHER	Exercise training	Resistance training of the lower limbs
BEHAVIORAL	Questionnaire	Physical activity questionnaire
PROCEDURE	Percutaneous muscle biopsy	Muscle biopsy of the vastus lateralis (m. quadriceps)
PROCEDURE	Blood sample	Venous blood sample

Timeline

• Start date: 2022-09-15
• Primary completion: 2023-10-15
• Completion: 2023-12-31
• First posted: 2022-10-07
• Last updated: 2023-03-31

Locations

1 site across 1 country: Belgium