NCT05539261

Research on Neurological Prognosis of Patients Undergoing Heart Valve Surgery

Brain Protection and Neurological Prognosis in Patients With Heart Valve Disease Undergoing Cardiopulmonary Bypass Operation

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Nanjing University of Traditional Chinese Medicine · Academic / Other
• Sex: All
• Age: 45 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to clarify the changes of neurocognitive function of patients undergoing cardiac valve disease before and after surgical treatment under cardiopulmonary bypass operation, and to predict the neurological prognosis of such patients through combined imaging technology, so as to improve and avoid the occurrence of postoperative neurological dysfunction in such patients.

Detailed description

This study focuses on brain protection in patients with heart disease. The preoperative brain imaging and consciousness and cognition evaluation results, intraoperative brain monitoring indicators, adverse events of neurological function, brain imaging and consciousness and cognition evaluation results during the postoperative and follow-up periods were recorded. At the same time, serum markers related to perioperative neurological function were obtained to explore the relevant factors affecting neurocognitive function during the perioperative period. The research objectives to investigate the perioperative changes of neurocognitive function in patients undergoing heart valve surgery under cardiopulmonary bypass and the related factors affecting the prognosis of neurocognitive function.

Conditions

• Heart Valve Diseases
• Image

Interventions

Type	Name	Description
DEVICE	magnetic resonance image	Imaging data were collected in a strong magnetic field
DIAGNOSTIC_TEST	Neuropsychological scale	Multi dimensional neuropsychological test

Timeline

• Start date: 2022-09-10
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2022-09-14
• Last updated: 2022-09-14

Locations

1 site across 1 country: China