Trials / Recruiting
RecruitingNCT05522075
Reducing Blood Pressure in Mid-life Adult Binge Drinkers
Reducing Blood Pressure in Mid-life Adult Binge Drinkers: the Role of Microvascular Function and Sympathetic Activity
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 55 (estimated)
- Sponsor
- The University of Texas at Arlington · Academic / Other
- Sex
- All
- Age
- 50 Years – 64 Years
- Healthy volunteers
- Accepted
Summary
This study has two phases: Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers. Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers
Detailed description
During phase 1, we will measure blood pressure, microvascular function, and sympathetic nerve activity (baseline assessment) in mid-life adult binge drinkers, alcohol abstainers, and moderate drinkers. Only mid-life adult binge drinkers will enter Phase 2 and be randomized to the exercise training group and non-exercise control group. After 8 weeks of intervention, we will re-measure blood pressure, microvascular function, and sympathetic nerve activity (post-intervention assessment) in mid-life adult binge drinkers.
Conditions
- Alcohol Drinking
- Binge Drinking
- Blood Pressure
- Alcohol Abstinence
- Aging
- Lifestyle Factors
- Vasodilation
- Behavioral Problem
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Exercise Training | Subjects will be asked to perform exercise training (high-intensity interval training) under supervision, 3 times per week for 8 weeks. Each training session will last 40 minutes and will consist of 10-minute warm up at 70% of maximal heart rate (HRmax), four 4-minute intervals at 90% of HRmax with 3-min active recovery at 70% of HRmax and 5-minute cool down at 70% of HRmax. |
| BEHAVIORAL | Alcohol Abstinence Intervention | Subjects will be asked to abstain from alcohol for 8 weeks. Education materials and bi-weekly consultations will be provided. |
Timeline
- Start date
- 2022-11-21
- Primary completion
- 2026-04-30
- Completion
- 2026-04-30
- First posted
- 2022-08-30
- Last updated
- 2026-02-23
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT05522075. Inclusion in this directory is not an endorsement.