NCT05499117

Efficacy and Safety of Light Therapy in the Treatment of Non-seasonal Depressive Disorder in Chinese Population

Efficacy and Safety of Light Therapy in the Treatment of Non-seasonal Depressive

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Shanghai Mental Health Center · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Depression is a kind of mental illness with high incidence, high recurrence and high disability. But so far, treatment remission rates for depression remain low. Therefore, it is necessary to develop more new treatments. Light therapy has been shown to be effective in treating depression with seasonal patterns. Although most studies have reported that light therapy is also effective in patients with depression without seasonal patterns, high-quality clinical studies are still rare and the conclusions are still controversial. In particular, it remains unclear whether light therapy is effective in treating depression without seasonal patterns in the Chinese population. In addition, there is a lack of biomarkers that predict the efficacy of light therapy. In conclusion, this study intends to conduct an ADD-ON randomized controlled study to clarify the efficacy and safety of light therapy as synergistic therapy in patients with depression without seasonal patterns, and to screen peripheral biomarkers related to efficacy using transcriptome sequencing technology. It is expected that this study can confirm the effectiveness and safety of light therapy as synergistic therapy, provide an evidence-based basis for the research and exploration of light therapy in Chinese depression population, and provide more options for the synergistic treatment of antidepressants in Chinese depression population.

Conditions

• Major Depressive Disorder

Interventions

Type	Name	Description
DEVICE	Light terapy	Carex Day-Light Classic, Light intensity is white Light, 10000UX, and color temperature is 4000K
DEVICE	pseudo-light therapy	The pseudo-light stimulation group was red light with intensity less than 100lux

Timeline

• Start date: 2022-02-01
• Primary completion: 2023-07-31
• Completion: 2023-07-31
• First posted: 2022-08-12
• Last updated: 2022-08-12

Locations

1 site across 1 country: China