NCT05483465

The Effect of NAD Supplementation on Brain Vascular Health in Aging

Effects of NAD Restoration on Neurovascular Coupling in Community Dwelling Older Adults

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 214 (estimated)
• Sponsor: University of Oklahoma · Academic / Other
• Sex: All
• Age: 60 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.

Detailed description

This study is designed to test the hypothesis that restoration of Nicotinamide Adenine Dinucleotide (NAD) levels with Nicotinamide Riboside (NR) in older adults will improve neurovascular coupling (NVC) responses and micro- and macrovascular endothelial function. This hypothesis will be tested by assessing the effects of treatment with oral NR (1g/day per os for 8 weeks) or placebo (8 weeks) in community dwelling older adults (60-85 years of age).

Conditions

• Aging

Interventions

Type	Name	Description
DRUG	Nicotinamide riboside	Oral NR, 1g/day per os for 8 weeks
DRUG	Placebo	Visually identical pill to NR, daily per os for 8 weeks

Timeline

• Start date: 2023-05-03
• Primary completion: 2027-06-01
• Completion: 2027-12-01
• First posted: 2022-08-02
• Last updated: 2026-04-01

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study