NCT05476627

Risk Factors and Multiomics Study of Chronic Kidney Disease Caused by Metabolic Diseases

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

With the development of China's economy, people's living standard have improved, and the dietary structure have changed. Metabolic diseases, such as hypertension, diabetes, hyperuricemia and obesity have gradually become an important health burden in China. The pathophysiological mechanism of renal injury caused by metabolic diseases has always been a hotspot of research. Currently, it is believed that various mechanisms including the activation of Renin-Angiotensin-Aldosterone System, vascular endothelial dysfunction, oxidative stress and inflammatory process may be involved. Although there are differences in renal pathological manifestations caused by different metabolic diseases, the kidney will eventually present ischemic changes and fibrosis with the progression of the disease. So there must be some common pathogenesis. This study is designed to build a disease cohort of patients with chronic kidney disease caused by metabolic diseases, to identify risk factors leading to disease progression and to explore biomarkers for early diagnosis and treatment of kidney damage.

Conditions

• Chronic Kidney Diseases
• Hypertension
• Diabetes Mellitus
• Hyperuricemia
• Obesity

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Biomarkers	Blood,urine and imaging biomarkers for early diagnosis and prediction of prognosis.

Timeline

• Start date: 2022-07-01
• Primary completion: 2025-07-01
• Completion: 2027-07-01
• First posted: 2022-07-27
• Last updated: 2022-08-16

Locations

1 site across 1 country: China